#60: How to Reverse Ageing (Part 4 of 4). The Future of Longevity Research with Professor David Sinclair

15 Jul 2020

My guest on the show today is David A. Sinclair, Ph.D, a tenured Professor of Genetics at Harvard Medical School, he is best known for his work on genes and small molecules that delay ageing, including the Sirtuins, NAD precursors, Resveratrol and other epigenetic modifiers. 

He has received many honours including a feature on TIME magazine’s list of the “100 most influential people in the world” and this podcast episode about how to treat and reverse ageing will give you a glimpse into why he is so deserving.

On the show we talk about:

  • The hallmarks of ageing and why to distinguish it as a disease
  • Instead of trying to tackle each one of the 8 central tenants of ageing, how Prof is looking at the epigenome
  • Sirtuins and their role in ageing, DNA repair and gene expression
  • AMPK, MTor, Sirtuins as regulators of lifespan and defence pathways
  • Methods of fighting ageing and activating the body’s natural defence systems
  • Energy restriction, aerobic exercise, sauna and cold shock therapy
  • energy restriction, exercise triggering hypoxia, sauna, cold shock therapy,
  • NAD and NAD precursors, Metformin, rapamycin and resveratrol as molecules that can improve ageing
  • Why we need to treat ageing like a disease, which forms the foundation of multiple diseases. If we cure ageing, we cure a lot.
  • The ethical considerations of increasing lifespan


Do check out David’s work and his latest book - Lifespan - Why We Age and Why We Don’t Have To.

All other social media links are noted here below.

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"And then the question you can ask yourself - if you were not to age, would you get sick, would you get diseases?  Im arguing that you wouldnt.  

Now bad stuff can still happen, you can have mutations that cause disease - and cancer is one of those.  But I think its important to realise that our bodies are capable of great healing, they are capable of killing cancer cells on their own (through the immune system) and that the breakdown of those processes, in the large part, is the reason why we get sick"

Professor David Sinclair

What a fantastic guest and I absolutely love Davids work and what hes doing in his field - its so inspiring and I was delighted to be able to have David on the show as a guest.
I hope you really enjoyed this episode alongside the other three that weve done in this short series on How to Reverse Ageing - Id love to get your feedback , do let me know on social media if youve enjoyed these episodes!

GUEST: Professor David Sinclair

David A. Sinclair, Ph.D. is a tenured Professor of Genetics at Harvard Medical School, co-Director of the Paul F. Glenn Center for the Biology of Aging Research at Harvard Medical School, and Con-joint Professor, at the University of New South Wales, Sydney. He is best known for his work on genes and small molecules that delay aging, including the Sirtuins, NAD precursors, and other epigenetic modifiers. He serves as co-chief editor of the scientific journal Aging and has received 35 honors including being one of Australia's leading scientists under 45, the Australian Medical Research Medal, the NIH Director’s Pioneer award, TIME magazine’s list of the “100 most influential people in the world” (2014) and the “Top 50 people in Healthcare” (2018). He was elected an Officer of the Order of Australia in 2018.   Websites to View for Professor Sinclair: medapps.med.harvard.edu/agingresearch/  (Harvard Lab); medicalsciences.med.unsw.edu.au/people/professor-david-sinclair  (UNSW Lab);

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with Professor David Sinclair

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